HitPredict

Interactor 1: MP2K2 (P36507)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene: MAP2K2

Interactor 2: HNRPK (P61978)
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)
Gene: HNRNPK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005925 - focal adhesion
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 400 Hs			1 463
+	Hs
		903894 MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14		HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00
+	Hs
		625295 CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16		HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00
+	Hs
		805373 MP2K3_HUMAN (15-388): 8.33e-102: 307: 32.47		HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00
+	Dm
		112942 DSOR1_DROME (17-397): 1.66e-125: 369: 61.16		M9NF14_DROME (115-458): 5.28e-26: 113: 17.77
+	Hs
		682197 AKT2_HUMAN (31-365): 1.76e-125: 372: 20.95		FUBP2_HUMAN (200-463): 3.03e-12: 70.9: 14.29
+	Hs
		681965 AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12		FUBP2_HUMAN (200-463): 3.03e-12: 70.9: 14.29
+	Hs
		625452 CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16		PCBP2_HUMAN (23-131): 1.39e-12: 70.9: 23.21
+	Hs
		625540 CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16		FUBP2_HUMAN (200-463): 3.03e-12: 70.9: 14.29
+	Hs
		625451 CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16		PCBP1_HUMAN (23-127): 3.42e-12: 69.7: 23.15
+	Hs
		625547 CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16		FUBP1_HUMAN (300-460): 2.19e-09: 61.6: 19.64
+	Hs
		128029 CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16		IF2B3_HUMAN (272-463): 9e-09: 59.7: 14.57
+	Hs
		128018 KAPCA_HUMAN (32-347): 6.67e-122: 358: 22.99		IF2B3_HUMAN (272-463): 9e-09: 59.7: 14.57
+	Hs
		1027410 STK3_HUMAN (54-390): 1.33e-108: 329: 30.37		FUBP2_HUMAN (200-463): 3.03e-12: 70.9: 14.29
+	Hs
		127987 CDK1_HUMAN (69-375): 8.1e-111: 328: 24.76		IF2B3_HUMAN (272-463): 9e-09: 59.7: 14.57
+	Hs
		805422 MP2K3_HUMAN (15-388): 8.33e-102: 307: 32.47		PCBP1_HUMAN (23-127): 3.42e-12: 69.7: 23.15