HitPredict

Interactor 1: MP2K2 (P36507)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene: MAP2K2

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	35271311, 32707033, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 247
+	Hs
		909461 MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	At
		1280891 CIPKC_ARATH (52-362): 2.02e-124: 370: 21.25		14337_ARATH (3-244): 3.18e-142: 400: 60.25
+	At
		788672 CIPKC_ARATH (52-362): 2.02e-124: 370: 21.25		14333_ARATH (1-244): 4.4e-142: 400: 61.79
+	Hs
		734905 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		904460 MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	At
		965360 CIPKC_ARATH (52-362): 2.02e-124: 370: 21.25		14332_ARATH (4-244): 1.39e-141: 398: 61.32
+	Hs
		681770 AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		681766 AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		904468 KPCT_HUMAN (15-364): 1.46e-121: 369: 22.34		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		972180 MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		734920 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		683280 MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		926945 MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		683173 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		734907 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		681776 AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		646815 MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		646688 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		646820 KPCT_HUMAN (15-364): 1.46e-121: 369: 22.34		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		681682 AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16