HitPredict

Interactor 1: MP2K2 (P36507)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene: MAP2K2

Interactor 2: RACK1 (P63244)
Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)]
Gene: RACK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 400 Hs			1 317
+	Hs
		929406 MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		625337 CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		609659 KAPCG_HUMAN (32-368): 1.73e-122: 360: 21.63		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		805384 MP2K3_HUMAN (15-388): 8.33e-102: 307: 32.47		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		734902 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		WDR5_HUMAN (3-219): 3.42e-62: 202: 26.70
+	Sc
		565470 PHO85_YEAST (68-372): 5.74e-110: 326: 25.40		NLE1_YEAST (59-316): 3.4e-70: 228: 20.92
+	Dm
		186204 AKT1_DROME (53-350): 7.38e-123: 370: 21.77		GBLP_DROME (93-316): 4.19e-49: 167: 22.88
+	Hs
		854722 MP2K6_HUMAN (66-383): 7.24e-64: 209: 36.89		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		625202 CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16		LIS1_HUMAN (144-316): 6.1e-46: 162: 23.43
+	Ce
		110184 GCK1_CAEEL (72-377): 8.25e-107: 330: 30.20		GBLP_CAEEL (50-316): 3e-58: 191: 25.61
+	At
		1105322 KIN10_ARATH (71-352): 3.12e-128: 380: 21.88		PRL1_ARATH (3-219): 1.27e-36: 138: 19.47
+	At
		955193 KIN11_ARATH (71-344): 2.46e-124: 370: 24.10		PRL1_ARATH (3-219): 1.27e-36: 138: 19.47
+	Hs
		414806 CDK1_HUMAN (69-375): 8.1e-111: 328: 24.76		LIS1_HUMAN (144-316): 6.1e-46: 162: 23.43
+	Hs
		972235 MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14		FBXW7_HUMAN (3-128): 4.32e-21: 95.4: 24.63
+	Hs
		681967 AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12		FBXW7_HUMAN (3-128): 4.32e-21: 95.4: 24.63
+	Hs
		625543 CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16		FBXW7_HUMAN (3-128): 4.32e-21: 95.4: 24.63
+	Hs
		1027412 STK3_HUMAN (54-390): 1.33e-108: 329: 30.37		FBXW7_HUMAN (3-128): 4.32e-21: 95.4: 24.63
+	Hs
		415016 CDK1_HUMAN (69-375): 8.1e-111: 328: 24.76		FBXW7_HUMAN (3-128): 4.32e-21: 95.4: 24.63
+	At
		189107 M2K9_ARATH (71-370): 2.18e-48: 168: 33.66		GBLPA_ARATH (100-317): 3.63e-49: 168: 26.41