HitPredict

Interactor 1: MP2K2 (P36507)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene: MAP2K2

Interactor 2: TBA1C (Q9BQE3)
Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]
Gene: TUBA1C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	31980649, 33961781, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005874 - microtubule GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 449
+	Hs
		625584 CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16		TBA1C_HUMAN (1-449): 0: 733: 100.00
+	Hs
		734911 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		TBA4A_HUMAN (1-448): 0: 724: 96.21
+	Hs
		734910 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		TBA1B_HUMAN (1-439): 0: 717: 99.09
+	Hs
		734964 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		TBA1A_HUMAN (1-439): 0: 715: 99.09
+	Hs
		681913 AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12		TBA1A_HUMAN (1-439): 0: 715: 99.09
+	Dm
		415650 DSOR1_DROME (17-397): 1.66e-125: 369: 61.16		TBA3_DROME (1-439): 0: 710: 96.81
+	Hs
		428055 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		428041 AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		734912 MP2K2_HUMAN (1-400): 1.09e-125: 370: 100.00		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		681781 AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		1023101 STK4_HUMAN (41-377): 2.43e-109: 331: 28.74		TBA1C_HUMAN (1-449): 0: 733: 100.00
+	Hs
		625344 CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		933421 STK4_HUMAN (41-377): 2.43e-109: 331: 28.74		TBA4A_HUMAN (1-448): 0: 724: 96.21
+	Hs
		933422 MP2K5_HUMAN (8-395): 7.03e-103: 313: 36.46		TBA4A_HUMAN (1-448): 0: 724: 96.21
+	Hs
		933188 MP2K5_HUMAN (8-395): 7.03e-103: 313: 36.46		TBA1B_HUMAN (1-439): 0: 717: 99.09
+	Ce
		110168 GCK1_CAEEL (72-377): 8.25e-107: 330: 30.20		O18688_CAEEL (1-439): 0: 699: 87.70
+	Hs
		933777 STK4_HUMAN (41-377): 2.43e-109: 331: 28.74		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		414682 CDK1_HUMAN (69-375): 8.1e-111: 328: 24.76		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		428177 MP2K5_HUMAN (8-395): 7.03e-103: 313: 36.46		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		933781 MP2K5_HUMAN (8-395): 7.03e-103: 313: 36.46		TBB4B_HUMAN (1-437): 0: 697: 40.73