HitPredict

Interactor 1: VATE1 (P36543)
V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (V-ATPase 31 kDa subunit) (p31) (Vacuolar proton pump subunit E 1)
Gene: ATP6V1E1

Interactor 2: VATA (P38606)
V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha)
Gene: ATP6V1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

The method score is based on:

Property	Details
Experiments	35271311, 21674799
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	ATP-synt_ab~vATP-synt_E, ATP-synt_ab_N~vATP-synt_E
Common GO terms	GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain GO:0005765 - lysosomal membrane GO:0005829 - cytosol GO:0005902 - microvillus GO:0016241 - regulation of macroautophagy and 7 others more... GO:0016324 - apical plasma membrane GO:0016469 - proton-transporting two-sector ATPase complex GO:0030665 - clathrin-coated vesicle membrane GO:0046961 - proton-transporting ATPase activity, rotational mechanism GO:0070062 - extracellular exosome GO:0097401 - synaptic vesicle lumen acidification GO:1902600 - proton transmembrane transport
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	226
Hs

1	617

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024