HitPredict

Interactor 1: PCK2 (P36583)
Protein kinase C-like 2 (EC 2.7.11.13)
Gene: PCK2

Interactor 2: RHO2 (Q10133)
GTP-binding protein rho2
Gene: RHO2

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	10504305, 18793338
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, HR1~Ras, Pkinase~Ras
Common GO terms	GO:0005634 - nucleus GO:0032153 - cell division site GO:0070610 - regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process GO:1902660 - negative regulation of glucose mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1016 Sp			1 200
+	Sp
		736865 PCK2_SCHPO (1-1016): 0: 884: 100.00		RHO5_SCHPO (7-199): 1.85e-90: 265: 53.06
+	Sp
		736859 PCK2_SCHPO (1-1016): 0: 884: 100.00		RHO1_SCHPO (1-199): 1.12e-83: 248: 55.88
+	Sp
		736857 PCK2_SCHPO (1-1016): 0: 884: 100.00		CDC42_SCHPO (7-199): 1.8e-76: 229: 44.56
+	Sp
		736864 PCK2_SCHPO (1-1016): 0: 884: 100.00		RHO4_SCHPO (9-177): 8.63e-59: 184: 53.80
+	Sp
		736856 PCK1_SCHPO (1-1002): 0: 743: 45.40		RHO5_SCHPO (7-199): 1.85e-90: 265: 53.06
+	Sp
		736852 PCK1_SCHPO (1-1002): 0: 743: 45.40		RHO2_SCHPO (1-200): 5.27e-85: 251: 100.00
+	Sp
		736851 PCK1_SCHPO (1-1002): 0: 743: 45.40		RHO1_SCHPO (1-199): 1.12e-83: 248: 55.88
+	Sp
		736850 PCK1_SCHPO (1-1002): 0: 743: 45.40		CDC42_SCHPO (7-199): 1.8e-76: 229: 44.56
+	Sp
		736855 PCK1_SCHPO (1-1002): 0: 743: 45.40		RHO4_SCHPO (9-177): 8.63e-59: 184: 53.80
+	Hs
		915625 KPCD_HUMAN (273-1009): 0: 558: 25.88		RHOB_HUMAN (7-197): 1.16e-91: 268: 57.07
+	Hs
		436269 KPCD_HUMAN (273-1009): 0: 558: 25.88		RHOC_HUMAN (10-199): 2.12e-83: 246: 56.32
+	Rn
		448411 KPCD_RAT (273-1009): 0: 560: 26.01		RAC1_RAT (9-199): 1.38e-79: 237: 48.69
+	Dm
		52723 PKN_DROME (12-1006): 4.63e-180: 557: 25.42		RAC1_DROME (9-199): 3.56e-77: 231: 47.12
+	Hs
		900406 KPCD_HUMAN (273-1009): 0: 558: 25.88		RHOA_HUMAN (10-199): 4.08e-76: 228: 57.90
+	Dm
		52724 PKN_DROME (12-1006): 4.63e-180: 557: 25.42		RHO1_DROME (10-199): 1.22e-74: 224: 56.32
+	Hs
		894645 M3K4_HUMAN (5-949): 1.09e-166: 532: 12.85		CDC42_HUMAN (9-199): 4.58e-82: 243: 47.12
+	Hs
		436326 PKN2_HUMAN (112-1006): 3.79e-170: 525: 24.54		RHOC_HUMAN (10-199): 2.12e-83: 246: 56.32
+	Hs
		925778 M3K4_HUMAN (5-949): 1.09e-166: 532: 12.85		RAC1_HUMAN (9-199): 1.38e-79: 237: 48.69
+	Hs
		894056 PKN2_HUMAN (112-1006): 3.79e-170: 525: 24.54		CDC42_HUMAN (9-199): 4.58e-82: 243: 47.12
+	Hs
		545401 PKN2_HUMAN (112-1006): 3.79e-170: 525: 24.54		RAC2_HUMAN (9-199): 4.91e-76: 228: 45.55