HitPredict

Interactor 1: DHSO (P36624)
Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) (Polyol dehydrogenase) (Protein tms1)
Gene: tms1

Interactor 2: DHSO (P36624)
Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) (Polyol dehydrogenase) (Protein tms1)
Gene: tms1

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.806

Property	Details
Experiments	26771498, 23695164
Identification Methods	two hybrid, protein complementation assay, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ADH_N~ADH_N, ADH_N~ADH_zinc_N, ADH_zinc_N~ADH_zinc_N
Common GO terms	GO:0003939 - L-iditol 2-dehydrogenase (NAD+) activity GO:0005829 - cytosol GO:0006062 - sorbitol catabolic process GO:0008270 - zinc ion binding GO:0046526 - D-xylulose reductase activity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 360 Sp			1 360
+	Ce
		1094367 Q21702_CAEEL (1-357): 3.59e-111: 329: 37.54		Q21702_CAEEL (1-357): 3.59e-111: 329: 37.54
+	Hs
		1378436 V9HW89_HUMAN (3-358): 1.73e-110: 328: 36.80		V9HW89_HUMAN (3-358): 1.73e-110: 328: 36.80
+	Hs
		961970 DHSO_HUMAN (3-358): 6.88e-110: 326: 36.52		DHSO_HUMAN (3-358): 6.88e-110: 326: 36.52
+	Sc
		723838 DHSO1_YEAST (4-359): 2.16e-109: 325: 47.19		DHSO2_YEAST (4-359): 6.19e-109: 324: 46.91
+	Sc
		991972 DHSO2_YEAST (4-359): 6.19e-109: 324: 46.91		DHSO2_YEAST (4-359): 6.19e-109: 324: 46.91
+	Dm
		332042 O96299_DROME (1-357): 6.08e-108: 321: 41.46		O97479_DROME (1-357): 1.71e-107: 320: 42.02
+	Ce
		1094368 Q21702_CAEEL (1-357): 3.59e-111: 329: 37.54		Q21703_CAEEL (1-357): 2.04e-102: 307: 35.85
+	At
		415121 ADH1_ARATH (4-357): 1.1e-104: 314: 22.19		ADH1_ARATH (4-357): 1.1e-104: 314: 22.19
+	Ph
		223404 TDH_PYRHO (1-354): 2.8e-101: 304: 26.61		TDH_PYRHO (1-354): 2.8e-101: 304: 26.61
+	Hs
		333616 ADH1B_HUMAN (4-348): 1.58e-100: 303: 23.00		ADH1G_HUMAN (4-348): 2.55e-99: 300: 22.73
+	Hs
		333619 ADH1B_HUMAN (4-348): 1.58e-100: 303: 23.00		ADH1A_HUMAN (4-348): 8.59e-99: 299: 23.00
+	Hs
		515134 ADHX_HUMAN (4-357): 8.8e-100: 301: 20.89		ADHX_HUMAN (4-357): 8.8e-100: 301: 20.89
+	Sc
		423554 ADH3_YEAST (1-354): 5.81e-99: 299: 20.39		ADH3_YEAST (1-354): 5.81e-99: 299: 20.39
+	Sc
		333659 ADH3_YEAST (1-354): 5.81e-99: 299: 20.39		ADH1_YEAST (1-354): 3.4e-94: 286: 19.83
+	At
		1227811 ADHL6_ARATH (4-359): 1.05e-95: 291: 20.57		ADHL6_ARATH (4-359): 1.05e-95: 291: 20.57