HitPredict

Interactor 1: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Interactor 2: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.802

Property	Details
Experiments	26496610, 21382349
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Metallophos
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0019901 - protein kinase binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 323 Hs			1 375
+	Hs
		915208 PP2AB_HUMAN (8-312): 2.02e-178: 497: 46.73		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		737677 PP1G_HUMAN (1-323): 0: 603: 100.00		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		737734 PP1G_HUMAN (1-323): 0: 603: 100.00		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		891662 PP1A_HUMAN (1-323): 0: 579: 90.66		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Mm
		906230 PP1A_MOUSE (1-323): 0: 579: 90.36		ACTG_MOUSE (1-375): 0: 604: 100.00
+	Hs
		905825 PP1A_HUMAN (1-323): 0: 579: 90.66		ACTS_HUMAN (2-375): 0: 594: 93.85
+	Hs
		891663 PP1B_HUMAN (1-322): 0: 560: 86.89		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		906403 PP1B_HUMAN (1-322): 0: 560: 86.89		ACTG_HUMAN (1-375): 0: 604: 100.00
+	Hs
		906406 PP1B_HUMAN (1-322): 0: 560: 86.89		ACTC_HUMAN (2-375): 0: 595: 94.39
+	Hs
		906407 PP1B_HUMAN (1-322): 0: 560: 86.89		ACTS_HUMAN (2-375): 0: 594: 93.85
+	Sc
		696382 PP12_YEAST (3-304): 0: 550: 85.76		ACT_YEAST (1-375): 0: 592: 89.07