HitPredict

Interactor 1: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.672

Property	Details
Experiments	30344098, 14670976, 12567184, 19070599
Identification Methods	affinity chromatography technology, biochemical
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030182 - neuron differentiation GO:0032922 - circadian regulation of gene expression and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 323 Hs			1 482
+	Hs
		737952 PP1G_HUMAN (1-323): 0: 603: 100.00		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Mm
		140248 PP1A_MOUSE (1-323): 0: 579: 90.36		HDAC1_MOUSE (1-482): 0: 672: 99.38
+	Hs
		905880 PP1A_HUMAN (1-323): 0: 579: 90.66		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		177250 PP1A_HUMAN (1-323): 0: 579: 90.66		HDAC3_HUMAN (9-434): 0: 574: 57.94
+	Hs
		738016 PP1G_HUMAN (1-323): 0: 603: 100.00		HDAC8_HUMAN (32-371): 2.54e-139: 407: 43.11
+	Hs
		906544 PP1B_HUMAN (1-322): 0: 560: 86.89		HDAC7_HUMAN (10-410): 1.09e-137: 421: 21.56
+	Hs
		930935 PP2AA_HUMAN (8-312): 5.65e-178: 496: 46.08		HDAC7_HUMAN (10-410): 1.09e-137: 421: 21.56
+	Hs
		738102 PP1G_HUMAN (1-323): 0: 603: 100.00		HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78
+	Hs
		906183 PP1A_HUMAN (1-323): 0: 579: 90.66		HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78