HitPredict

Interactor 1: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Interactor 2: ASPP2 (Q13625)
Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)
Gene: TP53BP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.763

Property	Details
Experiments	24366813, 32296183, 25416956, 26186194, 27880917, 28514442, 28330616, 33961781, 23080069, 21382349, 21988832, 21998301, 18448430
Identification Methods	affinity chromatography technology, two hybrid, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid, pull down, peptide array
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007049 - cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 323 Hs			1 1128
+	Hs
		905884 PP1A_HUMAN (1-323): 0: 579: 90.66		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Mm
		93784 PP1A_MOUSE (1-323): 0: 579: 90.36		E9QJU8_MOUSE (1-1128): 0: 576: 90.79
+	Hs
		737760 PP1G_HUMAN (1-323): 0: 603: 100.00		Q05BL1_HUMAN (90-1128): 2.47e-152: 484: 99.90
+	Hs
		905849 PP1A_HUMAN (1-323): 0: 579: 90.66		Q05BL1_HUMAN (90-1128): 2.47e-152: 484: 99.90
+	Hs
		737981 PP1G_HUMAN (1-323): 0: 603: 100.00		ASPP1_HUMAN (1-1128): 4.45e-135: 439: 45.38
+	Mm
		906278 PP1A_MOUSE (1-323): 0: 579: 90.36		ASPP1_MOUSE (1-1128): 5.97e-136: 441: 45.12
+	Hs
		737941 PP1G_HUMAN (1-323): 0: 603: 100.00		IASPP_HUMAN (416-1127): 1.13e-53: 204: 21.65
+	Mm
		906260 PP1A_MOUSE (1-323): 0: 579: 90.36		IASPP_MOUSE (390-1127): 9.81e-55: 207: 22.17
+	Hs
		738001 PP1G_HUMAN (1-323): 0: 603: 100.00		BARD1_HUMAN (676-1036): 1.54e-45: 179: 16.83
+	Hs
		737978 PP1G_HUMAN (1-323): 0: 603: 100.00		PP16A_HUMAN (939-1037): 6.43e-21: 99: 33.33
+	Hs
		737999 PP1G_HUMAN (1-323): 0: 603: 100.00		PP16B_HUMAN (945-1037): 1.27e-19: 96.1: 36.56
+	Hs
		161322 PP1G_HUMAN (1-323): 0: 603: 100.00		MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89
+	Mm
		926555 PP1G_MOUSE (1-323): 0: 602: 99.69		MYPT1_MOUSE (891-1059): 3.49e-16: 86: 26.74
+	Hs
		738024 PP1G_HUMAN (1-323): 0: 603: 100.00		PP12C_HUMAN (906-1034): 4.04e-12: 72.6: 23.88
+	Hs
		225129 PP1G_HUMAN (1-323): 0: 603: 100.00		MYPT2_HUMAN (947-1035): 1.24e-11: 71.4: 33.71
+	Hs
		161347 PP1A_HUMAN (1-323): 0: 579: 90.66		MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89
+	Mm
		906366 PP1A_MOUSE (1-323): 0: 579: 90.36		MYPT1_MOUSE (891-1059): 3.49e-16: 86: 26.74
+	Mm
		906252 PP1A_MOUSE (1-323): 0: 579: 90.36		PP12C_MOUSE (906-1036): 3.9e-13: 76: 24.27
+	Mm
		906293 PP1A_MOUSE (1-323): 0: 579: 90.36		MYPT2_MOUSE (947-1035): 2.73e-12: 73.3: 33.71
+	Hs
		225132 PP1A_HUMAN (1-323): 0: 579: 90.66		MYPT2_HUMAN (947-1035): 1.24e-11: 71.4: 33.71