HitPredict

Interactor 1: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Interactor 2: AAK1 (Q2M2I8)
AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)
Gene: AAK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0098793 - presynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 323 Hs			1 961
+	Hs
		905937 PP1A_HUMAN (1-323): 0: 579: 90.66		AAK1_HUMAN (1-961): 0: 720: 100.00
+	Hs
		738071 PP1G_HUMAN (1-323): 0: 603: 100.00		BMP2K_HUMAN (37-767): 7.31e-125: 409: 47.28
+	Mm
		926532 PP1G_MOUSE (1-323): 0: 602: 99.69		TNIK_MOUSE (24-782): 6.51e-116: 388: 13.73
+	Hs
		906157 PP1A_HUMAN (1-323): 0: 579: 90.66		BMP2K_HUMAN (37-767): 7.31e-125: 409: 47.28
+	Hs
		738092 PP1G_HUMAN (1-323): 0: 603: 100.00		MARK1_HUMAN (4-739): 6.05e-119: 383: 17.11
+	Hs
		159165 PP1G_HUMAN (1-323): 0: 603: 100.00		CSKP_HUMAN (43-677): 4.25e-116: 379: 16.03
+	Hs
		681698 PP1G_HUMAN (1-323): 0: 603: 100.00		AKT1_HUMAN (7-386): 1.25e-118: 373: 16.50
+	Hs
		906610 PP1B_HUMAN (1-322): 0: 560: 86.89		BMP2K_HUMAN (37-767): 7.31e-125: 409: 47.28
+	Mm
		906234 PP1A_MOUSE (1-323): 0: 579: 90.36		TNIK_MOUSE (24-782): 6.51e-116: 388: 13.73
+	Mm
		682103 PP1A_MOUSE (1-323): 0: 579: 90.36		AKT1_MOUSE (7-386): 2.81e-119: 374: 16.75
+	Hs
		681767 PP1A_HUMAN (1-323): 0: 579: 90.66		AKT1_HUMAN (7-386): 1.25e-118: 373: 16.50
+	Hs
		229930 PP1G_HUMAN (1-323): 0: 603: 100.00		NUAK1_HUMAN (43-478): 6.05e-102: 334: 23.21
+	Hs
		681768 PP1B_HUMAN (1-322): 0: 560: 86.89		AKT1_HUMAN (7-386): 1.25e-118: 373: 16.50
+	Sc
		419841 PP12_YEAST (3-304): 0: 550: 85.76		SNF1_YEAST (26-507): 3.33e-114: 366: 19.56
+	Hs
		229937 PP1B_HUMAN (1-322): 0: 560: 86.89		NUAK1_HUMAN (43-478): 6.05e-102: 334: 23.21
+	Hs
		737663 PP1G_HUMAN (1-323): 0: 603: 100.00		NEK2_HUMAN (81-307): 4.75e-15: 80.9: 29.41
+	Mm
		193599 PP1A_MOUSE (1-323): 0: 579: 90.36		NEK2_MOUSE (81-307): 3.83e-15: 80.9: 29.41
+	Hs
		851308 PP1A_HUMAN (1-323): 0: 579: 90.66		NEK2_HUMAN (81-307): 4.75e-15: 80.9: 29.41
+	Hs
		851309 PP1B_HUMAN (1-322): 0: 560: 86.89		NEK2_HUMAN (81-307): 4.75e-15: 80.9: 29.41
+	Sc
		693084 PP12_YEAST (3-304): 0: 550: 85.76		CDC5_YEAST (52-307): 1.68e-17: 89.7: 31.72