HitPredict

Interactor 1: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Interactor 2: PHAR4 (Q8IZ21)
Phosphatase and actin regulator 4
Gene: PHACTR4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.695

Property	Details
Experiments	26186194, 28514442, 33961781, 23080069
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008157 - protein phosphatase 1 binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 323 Hs			1 702
+	Hs
		906013 PP1A_HUMAN (1-323): 0: 579: 90.66		PHAR4_HUMAN (1-702): 3.04e-73: 252: 100.00
+	Mm
		69836 PP1A_MOUSE (1-323): 0: 579: 90.36		B1AVP0_MOUSE (9-702): 1.87e-45: 174: 34.52
+	Hs
		906420 PP1B_HUMAN (1-322): 0: 560: 86.89		DYST_HUMAN (477-699): 6.74e-36: 148: 17.83
+	Hs
		90115 PP1A_HUMAN (1-323): 0: 579: 90.66		D6REX3_HUMAN (83-547): 1.42e-24: 111: 11.22
+	Hs
		737982 PP1G_HUMAN (1-323): 0: 603: 100.00		PHAR3_HUMAN (3-264): 1.31e-14: 79.3: 24.81
+	Hs
		906118 PP1A_HUMAN (1-323): 0: 579: 90.66		PHAR1_HUMAN (7-235): 1.63e-15: 82.4: 30.30
+	Hs
		905894 PP1A_HUMAN (1-323): 0: 579: 90.66		MDC1_HUMAN (61-694): 5.38e-15: 81.6: 10.31
+	Hs
		906082 PP1A_HUMAN (1-323): 0: 579: 90.66		PHAR3_HUMAN (3-264): 1.31e-14: 79.3: 24.81
+	Dm
		524625 PP12_DROME (5-303): 0: 551: 93.31		Q8IH02_DROME (15-161): 1.63e-18: 91.4: 32.43
+	Hs
		906563 PP1B_HUMAN (1-322): 0: 560: 86.89		PHAR3_HUMAN (3-264): 1.31e-14: 79.3: 24.81
+	Dm
		113980 PP1B_DROME (1-323): 0: 552: 82.48		M9PB30_DROME (4-350): 1.17e-11: 70.8: 11.86
+	Hs
		930846 PP2AA_HUMAN (8-312): 5.65e-178: 496: 46.08		MDC1_HUMAN (61-694): 5.38e-15: 81.6: 10.31