HitPredict

Interactor 1: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Interactor 2: IASPP (Q8WUF5)
RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein)
Gene: PPP1R13L

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.732

Property	Details
Experiments	26186194, 27880917, 28514442, 33961781, 24366813, 21998301
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 323 Hs			1 828
+	Mm
		906260 PP1A_MOUSE (1-323): 0: 579: 90.36		IASPP_MOUSE (1-825): 4.7e-107: 349: 88.12
+	Hs
		737795 PP1G_HUMAN (1-323): 0: 603: 100.00		ASPP2_HUMAN (25-828): 3.93e-78: 276: 24.48
+	Hs
		737760 PP1G_HUMAN (1-323): 0: 603: 100.00		Q05BL1_HUMAN (25-828): 1.71e-75: 267: 24.48
+	Hs
		905884 PP1A_HUMAN (1-323): 0: 579: 90.66		ASPP2_HUMAN (25-828): 3.93e-78: 276: 24.48
+	Mm
		93784 PP1A_MOUSE (1-323): 0: 579: 90.36		E9QJU8_MOUSE (56-828): 2.67e-75: 268: 23.96
+	Hs
		905849 PP1A_HUMAN (1-323): 0: 579: 90.66		Q05BL1_HUMAN (25-828): 1.71e-75: 267: 24.48
+	Hs
		737978 PP1G_HUMAN (1-323): 0: 603: 100.00		PP16A_HUMAN (640-738): 8.76e-19: 92.5: 28.28
+	Hs
		161322 PP1G_HUMAN (1-323): 0: 603: 100.00		MYPT1_HUMAN (581-760): 4.08e-17: 88.3: 25.00
+	Hs
		737999 PP1G_HUMAN (1-323): 0: 603: 100.00		PP16B_HUMAN (646-738): 4.71e-17: 87.5: 27.96
+	Hs
		906000 PP1A_HUMAN (1-323): 0: 579: 90.66		PPR27_HUMAN (621-737): 5.62e-27: 109: 33.05
+	Mm
		926555 PP1G_MOUSE (1-323): 0: 602: 99.69		MYPT1_MOUSE (581-760): 2.59e-16: 86: 25.00
+	Hs
		737981 PP1G_HUMAN (1-323): 0: 603: 100.00		ASPP1_HUMAN (26-584): 2.94e-13: 75.9: 14.99
+	Hs
		225129 PP1G_HUMAN (1-323): 0: 603: 100.00		MYPT2_HUMAN (640-746): 1.15e-10: 67.5: 27.52
+	Hs
		161347 PP1A_HUMAN (1-323): 0: 579: 90.66		MYPT1_HUMAN (581-760): 4.08e-17: 88.3: 25.00
+	Mm
		906366 PP1A_MOUSE (1-323): 0: 579: 90.36		MYPT1_MOUSE (581-760): 2.59e-16: 86: 25.00
+	Hs
		738024 PP1G_HUMAN (1-323): 0: 603: 100.00		PP12C_HUMAN (633-735): 9.35e-09: 61: 26.85
+	Mm
		906293 PP1A_MOUSE (1-323): 0: 579: 90.36		MYPT2_MOUSE (640-751): 2.14e-11: 69.8: 28.07
+	Hs
		225132 PP1A_HUMAN (1-323): 0: 579: 90.66		MYPT2_HUMAN (640-746): 1.15e-10: 67.5: 27.52
+	Mm
		906252 PP1A_MOUSE (1-323): 0: 579: 90.36		PP12C_MOUSE (633-737): 8.9e-10: 64.4: 26.36
+	Mm
		906278 PP1A_MOUSE (1-323): 0: 579: 90.36		ASPP1_MOUSE (13-641): 6.78e-09: 61.7: 9.98