HitPredict

Interactor 1: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Interactor 2: PP16A (Q96I34)
Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3)
Gene: PPP1R16A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	32296183, 23080069, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 323 Hs			1 528
+	Hs
		737999 PP1G_HUMAN (1-323): 0: 603: 100.00		PP16B_HUMAN (1-527): 5.45e-102: 319: 46.75
+	Hs
		906099 PP1A_HUMAN (1-323): 0: 579: 90.66		PP16B_HUMAN (1-527): 5.45e-102: 319: 46.75
+	Hs
		906079 PP1A_HUMAN (1-323): 0: 579: 90.66		PP16A_HUMAN (1-528): 1.56e-98: 309: 100.00
+	Hs
		905838 PP1A_HUMAN (1-323): 0: 579: 90.66		ANK2_HUMAN (9-524): 1.59e-89: 302: 16.01
+	Hs
		906572 PP1B_HUMAN (1-322): 0: 560: 86.89		PP16B_HUMAN (1-527): 5.45e-102: 319: 46.75
+	Hs
		906561 PP1B_HUMAN (1-322): 0: 560: 86.89		PP16A_HUMAN (1-528): 1.56e-98: 309: 100.00
+	Hs
		161322 PP1G_HUMAN (1-323): 0: 603: 100.00		MYPT1_HUMAN (22-341): 1.86e-75: 259: 37.07
+	Hs
		738024 PP1G_HUMAN (1-323): 0: 603: 100.00		PP12C_HUMAN (59-524): 4.7e-76: 257: 28.60
+	Mm
		926555 PP1G_MOUSE (1-323): 0: 602: 99.69		MYPT1_MOUSE (22-341): 7.45e-74: 254: 37.07
+	Mm
		906252 PP1A_MOUSE (1-323): 0: 579: 90.36		PP12C_MOUSE (27-513): 5.12e-83: 275: 29.80
+	Mm
		906293 PP1A_MOUSE (1-323): 0: 579: 90.36		MYPT2_MOUSE (33-493): 2.48e-76: 260: 27.56
+	Hs
		161347 PP1A_HUMAN (1-323): 0: 579: 90.66		MYPT1_HUMAN (22-341): 1.86e-75: 259: 37.07
+	Hs
		906116 PP1A_HUMAN (1-323): 0: 579: 90.66		PP12C_HUMAN (59-524): 4.7e-76: 257: 28.60
+	Mm
		906366 PP1A_MOUSE (1-323): 0: 579: 90.36		MYPT1_MOUSE (22-341): 7.45e-74: 254: 37.07
+	Hs
		161348 PP1B_HUMAN (1-322): 0: 560: 86.89		MYPT1_HUMAN (22-341): 1.86e-75: 259: 37.07
+	Gg
		907234 PP1B_CHICK (1-322): 0: 560: 86.89		MYPT1_CHICK (22-455): 4.53e-75: 257: 28.02
+	Hs
		225129 PP1G_HUMAN (1-323): 0: 603: 100.00		MYPT2_HUMAN (3-156): 1.54e-17: 88.4: 17.42
+	Hs
		225132 PP1A_HUMAN (1-323): 0: 579: 90.66		MYPT2_HUMAN (3-156): 1.54e-17: 88.4: 17.42
+	Hs
		225133 PP1B_HUMAN (1-322): 0: 560: 86.89		MYPT2_HUMAN (3-156): 1.54e-17: 88.4: 17.42
+	Hs
		3260 PP1B_HUMAN (1-322): 0: 560: 86.89		A0A0S2Z4Q8_HUMAN (213-324): 1.75e-10: 62: 33.04