HitPredict

Interactor 1: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Interactor 2: ASPP1 (Q96KQ4)
Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B)
Gene: PPP1R13B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.757

Property	Details
Experiments	24366813, 26186194, 27880917, 28514442, 28330616, 33961781, 23080069, 21382349, 21998301
Identification Methods	affinity chromatography technology, proximity labelling technology, two hybrid, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 323 Hs			1 1090
+	Hs
		737795 PP1G_HUMAN (1-323): 0: 603: 100.00		ASPP2_HUMAN (1-1090): 2e-141: 456: 46.13
+	Mm
		906278 PP1A_MOUSE (1-323): 0: 579: 90.36		ASPP1_MOUSE (1-1090): 2.37e-147: 471: 91.38
+	Hs
		905884 PP1A_HUMAN (1-323): 0: 579: 90.66		ASPP2_HUMAN (1-1090): 2e-141: 456: 46.13
+	Mm
		93784 PP1A_MOUSE (1-323): 0: 579: 90.36		E9QJU8_MOUSE (1-1090): 1.84e-134: 437: 45.87
+	Hs
		737760 PP1G_HUMAN (1-323): 0: 603: 100.00		Q05BL1_HUMAN (91-1090): 6.16e-104: 353: 44.56
+	Hs
		905849 PP1A_HUMAN (1-323): 0: 579: 90.66		Q05BL1_HUMAN (91-1090): 6.16e-104: 353: 44.56
+	Hs
		737940 PP1G_HUMAN (1-323): 0: 603: 100.00		DOT1L_HUMAN (94-844): 1.19e-72: 266: 16.97
+	Hs
		737941 PP1G_HUMAN (1-323): 0: 603: 100.00		IASPP_HUMAN (336-1089): 6.59e-57: 214: 22.46
+	Mm
		906260 PP1A_MOUSE (1-323): 0: 579: 90.36		IASPP_MOUSE (292-1089): 1.39e-55: 210: 22.35
+	Hs
		225129 PP1G_HUMAN (1-323): 0: 603: 100.00		MYPT2_HUMAN (857-997): 1.8e-38: 158: 32.62
+	Hs
		225132 PP1A_HUMAN (1-323): 0: 579: 90.66		MYPT2_HUMAN (857-997): 1.8e-38: 158: 32.62
+	Hs
		737978 PP1G_HUMAN (1-323): 0: 603: 100.00		PP16A_HUMAN (901-999): 6.07e-19: 93.8: 35.35
+	Hs
		737999 PP1G_HUMAN (1-323): 0: 603: 100.00		PP16B_HUMAN (907-999): 1.89e-17: 89.1: 38.71
+	Hs
		161322 PP1G_HUMAN (1-323): 0: 603: 100.00		MYPT1_HUMAN (821-1021): 1.28e-14: 81.1: 24.27
+	Mm
		926555 PP1G_MOUSE (1-323): 0: 602: 99.69		MYPT1_MOUSE (821-1021): 3.58e-14: 79.5: 22.82
+	Hs
		738024 PP1G_HUMAN (1-323): 0: 603: 100.00		PP12C_HUMAN (921-996): 2.71e-09: 63.3: 31.58
+	Hs
		161347 PP1A_HUMAN (1-323): 0: 579: 90.66		MYPT1_HUMAN (821-1021): 1.28e-14: 81.1: 24.27
+	Mm
		906366 PP1A_MOUSE (1-323): 0: 579: 90.36		MYPT1_MOUSE (821-1021): 3.58e-14: 79.5: 22.82
+	Mm
		906252 PP1A_MOUSE (1-323): 0: 579: 90.36		PP12C_MOUSE (870-998): 4.29e-10: 66: 23.88
+	Mm
		906293 PP1A_MOUSE (1-323): 0: 579: 90.36		MYPT2_MOUSE (921-997): 6.11e-10: 65.6: 32.47