HitPredict

Interactor 1: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Interactor 2: PP16B (Q96T49)
Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP)
Gene: PPP1R16B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 323 Hs			1 567
+	Hs
		906099 PP1A_HUMAN (1-323): 0: 579: 90.66		PP16B_HUMAN (1-567): 3.02e-132: 399: 100.00
+	Hs
		906572 PP1B_HUMAN (1-322): 0: 560: 86.89		PP16B_HUMAN (1-567): 3.02e-132: 399: 100.00
+	Hs
		225129 PP1G_HUMAN (1-323): 0: 603: 100.00		MYPT2_HUMAN (11-332): 5.76e-92: 304: 35.19
+	Hs
		161322 PP1G_HUMAN (1-323): 0: 603: 100.00		MYPT1_HUMAN (22-340): 3.45e-89: 298: 33.75
+	Mm
		926555 PP1G_MOUSE (1-323): 0: 602: 99.69		MYPT1_MOUSE (22-339): 4.06e-88: 295: 33.86
+	Hs
		737978 PP1G_HUMAN (1-323): 0: 603: 100.00		PP16A_HUMAN (1-566): 1.29e-91: 292: 46.40
+	Hs
		225132 PP1A_HUMAN (1-323): 0: 579: 90.66		MYPT2_HUMAN (11-332): 5.76e-92: 304: 35.19
+	Hs
		161347 PP1A_HUMAN (1-323): 0: 579: 90.66		MYPT1_HUMAN (22-340): 3.45e-89: 298: 33.75
+	Mm
		906366 PP1A_MOUSE (1-323): 0: 579: 90.36		MYPT1_MOUSE (22-339): 4.06e-88: 295: 33.86
+	Hs
		906079 PP1A_HUMAN (1-323): 0: 579: 90.66		PP16A_HUMAN (1-566): 1.29e-91: 292: 46.40
+	Hs
		225133 PP1B_HUMAN (1-322): 0: 560: 86.89		MYPT2_HUMAN (11-332): 5.76e-92: 304: 35.19
+	Mm
		906293 PP1A_MOUSE (1-323): 0: 579: 90.36		MYPT2_MOUSE (11-332): 2.09e-84: 284: 35.08
+	Hs
		738024 PP1G_HUMAN (1-323): 0: 603: 100.00		PP12C_HUMAN (49-519): 2.25e-76: 259: 26.14
+	Hs
		161348 PP1B_HUMAN (1-322): 0: 560: 86.89		MYPT1_HUMAN (22-340): 3.45e-89: 298: 33.75
+	Hs
		905838 PP1A_HUMAN (1-323): 0: 579: 90.66		ANK2_HUMAN (3-315): 2.12e-79: 275: 21.00
+	Mm
		906252 PP1A_MOUSE (1-323): 0: 579: 90.36		PP12C_MOUSE (27-480): 1.22e-82: 275: 26.84
+	Gg
		907234 PP1B_CHICK (1-322): 0: 560: 86.89		MYPT1_CHICK (22-338): 1.21e-87: 293: 33.96
+	Hs
		906561 PP1B_HUMAN (1-322): 0: 560: 86.89		PP16A_HUMAN (1-566): 1.29e-91: 292: 46.40
+	Hs
		906116 PP1A_HUMAN (1-323): 0: 579: 90.66		PP12C_HUMAN (49-519): 2.25e-76: 259: 26.14
+	Hs
		3260 PP1B_HUMAN (1-322): 0: 560: 86.89		A0A0S2Z4Q8_HUMAN (211-313): 6.9e-14: 72: 37.86