HitPredict

Interactor 1: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Interactor 2: DYRK4 (Q9NR20)
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1)
Gene: DYRK4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	21382349
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0046872 - metal ion binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 323 Hs			1 520
+	Hs
		625180 PP1G_HUMAN (1-323): 0: 603: 100.00		CDK2_HUMAN (101-411): 1.26e-140: 409: 27.04
+	Hs
		625299 PP1A_HUMAN (1-323): 0: 579: 90.66		CDK2_HUMAN (101-411): 1.26e-140: 409: 27.04
+	Mm
		926533 PP1G_MOUSE (1-323): 0: 602: 99.69		CDK2_MOUSE (101-411): 6.79e-131: 385: 23.77
+	Sp
		532285 PP11_SCHPO (7-322): 0: 555: 82.92		POM1_SCHPO (34-455): 1.57e-139: 431: 46.87
+	Hs
		737796 PP1G_HUMAN (1-323): 0: 603: 100.00		DYR1A_HUMAN (4-516): 2.5e-120: 372: 31.94
+	Hs
		625300 PP1B_HUMAN (1-322): 0: 560: 86.89		CDK2_HUMAN (101-411): 1.26e-140: 409: 27.04
+	Hs
		414790 PP1G_HUMAN (1-323): 0: 603: 100.00		CDK1_HUMAN (101-405): 3.7e-123: 364: 27.16
+	Mm
		509478 PP1G_MOUSE (1-323): 0: 602: 99.69		CDK1_MOUSE (101-405): 7.74e-122: 360: 27.80
+	Hs
		414846 PP1A_HUMAN (1-323): 0: 579: 90.66		CDK1_HUMAN (101-405): 3.7e-123: 364: 27.16
+	Sp
		383446 PP11_SCHPO (7-322): 0: 555: 82.92		CDK1_SCHPO (101-404): 1.17e-121: 360: 25.48
+	Hs
		625340 PP2AA_HUMAN (8-312): 5.65e-178: 496: 46.08		CDK2_HUMAN (101-411): 1.26e-140: 409: 27.04
+	Hs
		833705 PP1B_HUMAN (1-322): 0: 560: 86.89		CLK1_HUMAN (79-399): 1.17e-56: 198: 32.85
+	Zm
		40394 A0A1D6QAR4_MAIZE (4-251): 1.48e-148: 419: 75.00		A0A1D6N7V3_MAIZE (81-400): 3.1e-61: 216: 38.04