HitPredict

Interactor 1: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Interactor 2: SHOC2 (Q9UQ13)
Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog)
Gene: SHOC2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	26186194, 27880917, 28514442, 33961781, 24366813
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008157 - protein phosphatase 1 binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 323 Hs			1 582
+	Hs
		906202 PP1A_HUMAN (1-323): 0: 579: 90.66		SHOC2_HUMAN (1-582): 9.48e-110: 341: 100.00
+	Hs
		906638 PP1B_HUMAN (1-322): 0: 560: 86.89		SHOC2_HUMAN (1-582): 9.48e-110: 341: 100.00
+	Dm
		524646 PP12_DROME (5-303): 0: 551: 93.31		SUR8_DROME (90-581): 7.16e-101: 320: 63.62
+	Dm
		524622 PP12_DROME (5-303): 0: 551: 93.31		SCRIB_DROME (272-582): 8.65e-59: 214: 29.94
+	Hs
		737994 PP1G_HUMAN (1-323): 0: 603: 100.00		ERBIN_HUMAN (356-582): 9.64e-38: 151: 28.19
+	Hs
		738009 PP1G_HUMAN (1-323): 0: 603: 100.00		LRRC1_HUMAN (101-341): 9.34e-34: 136: 36.93
+	Hs
		906094 PP1A_HUMAN (1-323): 0: 579: 90.66		ERBIN_HUMAN (356-582): 9.64e-38: 151: 28.19
+	Hs
		737799 PP1G_HUMAN (1-323): 0: 603: 100.00		SCRIB_HUMAN (87-435): 6.42e-29: 124: 30.05
+	Hs
		906110 PP1A_HUMAN (1-323): 0: 579: 90.66		LRRC1_HUMAN (101-341): 9.34e-34: 136: 36.93
+	Hs
		905890 PP1A_HUMAN (1-323): 0: 579: 90.66		SCRIB_HUMAN (87-435): 6.42e-29: 124: 30.05
+	Hs
		906581 PP1B_HUMAN (1-322): 0: 560: 86.89		LRRC1_HUMAN (101-341): 9.34e-34: 136: 36.93
+	Hs
		906454 PP1B_HUMAN (1-322): 0: 560: 86.89		SCRIB_HUMAN (87-435): 6.42e-29: 124: 30.05
+	Hs
		737779 PP1G_HUMAN (1-323): 0: 603: 100.00		FLII_HUMAN (91-300): 3.4e-11: 68.6: 27.62
+	Mm
		906292 PP1A_MOUSE (1-323): 0: 579: 90.36		LRRC1_MOUSE (100-254): 4.93e-18: 89.4: 36.13
+	Hs
		905863 PP1A_HUMAN (1-323): 0: 579: 90.66		FLII_HUMAN (91-300): 3.4e-11: 68.6: 27.62
+	Hs
		906437 PP1B_HUMAN (1-322): 0: 560: 86.89		FLII_HUMAN (91-300): 3.4e-11: 68.6: 27.62