HitPredict

Interactor 1: FLT3 (P36888)
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
Gene: FLT3

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	1.00	0.770

Property	Details
Experiments	16684964
Identification Methods	pull down, affinity chromatography technology, competition binding, coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 993 Hs			1 593
+	Hs
		557099 PGFRA_HUMAN (47-992): 0: 595: 27.21		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		499259 KIT_HUMAN (57-986): 0: 594: 30.44		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		499236 KIT_HUMAN (57-986): 0: 594: 30.44		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		499261 KIT_HUMAN (57-986): 0: 594: 30.44		PTPRJ_HUMAN (146-528): 1.52e-109: 359: 30.55
+	Hs
		725305 TIE1_HUMAN (62-958): 3.29e-156: 493: 18.92		PTPRJ_HUMAN (146-528): 1.52e-109: 359: 30.55
+	Hs
		499281 KIT_HUMAN (57-986): 0: 594: 30.44		PTPRU_HUMAN (33-528): 3.63e-66: 236: 18.48
+	Hs
		441184 TIE1_HUMAN (62-958): 3.29e-156: 493: 18.92		PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29
+	Hs
		729644 VGFR2_HUMAN (55-536): 9.06e-33: 139: 14.02		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		617082 TIE1_HUMAN (62-958): 3.29e-156: 493: 18.92		PTPRG_HUMAN (33-527): 9.52e-62: 223: 17.05
+	Hs
		601501 FGFR2_HUMAN (8-273): 1.07e-26: 119: 11.69		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		507959 FGFR1_HUMAN (6-360): 2.83e-24: 111: 10.90		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		665808 VGFR2_HUMAN (55-536): 9.06e-33: 139: 14.02		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		601466 FGFR2_HUMAN (8-273): 1.07e-26: 119: 11.69		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		572587 VGFR1_HUMAN (74-537): 1.47e-36: 152: 14.31		PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91
+	Hs
		572628 VGFR1_HUMAN (74-537): 1.47e-36: 152: 14.31		PTPRJ_HUMAN (146-528): 1.52e-109: 359: 30.55
+	Hs
		729647 VGFR2_HUMAN (55-536): 9.06e-33: 139: 14.02		PTPRJ_HUMAN (146-528): 1.52e-109: 359: 30.55
+	Hs
		169163 MUSK_HUMAN (6-354): 1.85e-28: 125: 11.62		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		573600 VGFR3_HUMAN (70-533): 8.45e-27: 120: 14.15		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		507839 FGFR1_HUMAN (6-360): 2.83e-24: 111: 10.90		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Dm
		112212 M9MRE1_DROME (64-545): 2.24e-27: 122: 12.27		CSW_DROME (1-317): 7.21e-59: 212: 64.35