HitPredict

Interactor 1: FLT3 (P36888)
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
Gene: FLT3

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.690

Property	Details
Experiments	23246379
Identification Methods	anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 993 Hs			1 594
+	Mm
		403536 KIT_MOUSE (57-986): 0: 600: 30.08		VAV_MOUSE (36-592): 1.11e-137: 423: 14.55
+	Hs
		411619 FLT3_HUMAN (1-993): 0: 844: 97.89		LCK_HUMAN (420-589): 7.66e-49: 179: 19.66
+	Hs
		412062 FLT3_HUMAN (1-993): 0: 844: 97.89		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		433274 FLT3_HUMAN (1-993): 0: 844: 97.89		YES_HUMAN (441-592): 9.17e-47: 174: 20.89
+	Hs
		522826 FLT3_HUMAN (1-993): 0: 844: 97.89		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		433624 FLT3_HUMAN (1-993): 0: 844: 97.89		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Hs
		442785 FLT3_HUMAN (1-993): 0: 844: 97.89		HCK_HUMAN (406-593): 7.97e-46: 171: 18.78
+	Hs
		454802 FLT3_HUMAN (1-993): 0: 844: 97.89		FGR_HUMAN (441-593): 8.45e-46: 171: 18.63
+	Hs
		738179 FLT3_HUMAN (1-993): 0: 844: 97.89		BLK_HUMAN (449-593): 3.44e-45: 169: 22.82
+	Hs
		738192 FLT3_HUMAN (1-993): 0: 844: 97.89		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		738172 FLT3_HUMAN (1-993): 0: 844: 97.89		KSYK_HUMAN (459-593): 3.15e-16: 84.1: 27.94
+	Hs
		411567 KIT_HUMAN (57-986): 0: 594: 30.44		LCK_HUMAN (420-589): 7.66e-49: 179: 19.66
+	Hs
		411962 KIT_HUMAN (57-986): 0: 594: 30.44		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		433226 KIT_HUMAN (57-986): 0: 594: 30.44		YES_HUMAN (441-592): 9.17e-47: 174: 20.89
+	Rn
		595729 PGFRA_RAT (51-992): 0: 594: 27.00		LYN_RAT (409-593): 1.82e-46: 172: 17.19
+	Hs
		433539 KIT_HUMAN (57-986): 0: 594: 30.44		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Mm
		403538 KIT_MOUSE (57-986): 0: 600: 30.08		MATK_MOUSE (454-587): 2.8e-40: 155: 28.26
+	Mm
		403541 KIT_MOUSE (57-986): 0: 600: 30.08		GRB2_MOUSE (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		557088 PGFRA_HUMAN (47-992): 0: 595: 27.21		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Mm
		403542 KIT_MOUSE (57-986): 0: 600: 30.08		GRB10_MOUSE (57-148): 3.15e-14: 77.6: 69.15