HitPredict

Interactor 1: FLT3 (P36888)
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
Gene: FLT3

Interactor 2: SRPK1 (Q96SB4)
SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)
Gene: SRPK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005783 - endoplasmic reticulum GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 993 Hs			1 655
+	Hs
		557232 PGFRA_HUMAN (47-992): 0: 595: 27.21		SRPK1_HUMAN (1-655): 5.68e-157: 468: 94.64
+	Hs
		572674 VGFR1_HUMAN (74-537): 1.47e-36: 152: 14.31		SRPK1_HUMAN (1-655): 5.68e-157: 468: 94.64
+	Hs
		729340 VGFR3_HUMAN (70-533): 8.45e-27: 120: 14.15		SRPK1_HUMAN (1-655): 5.68e-157: 468: 94.64
+	Hs
		609245 FGFR3_HUMAN (20-260): 5.2e-21: 101: 9.09		SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97
+	Hs
		601517 FGFR2_HUMAN (8-273): 1.07e-26: 119: 11.69		KS6A1_HUMAN (1-359): 2.84e-81: 273: 14.32
+	Hs
		601482 FGFR2_HUMAN (8-273): 1.07e-26: 119: 11.69		KS6A3_HUMAN (1-353): 1.92e-78: 266: 13.83
+	Hs
		601516 FGFR2_HUMAN (8-273): 1.07e-26: 119: 11.69		KS6A2_HUMAN (1-374): 1.21e-78: 266: 14.00
+	Rn
		979772 FGFR1_RAT (6-360): 1.05e-23: 109: 11.86		KS6A1_RAT (1-359): 1.81e-82: 276: 14.58
+	Hs
		508016 FGFR1_HUMAN (6-360): 2.83e-24: 111: 10.90		KS6A1_HUMAN (1-359): 2.84e-81: 273: 14.32
+	Hs
		507919 FGFR1_HUMAN (6-360): 2.83e-24: 111: 10.90		KS6A3_HUMAN (1-353): 1.92e-78: 266: 13.83
+	Hs
		508015 FGFR1_HUMAN (6-360): 2.83e-24: 111: 10.90		KS6A2_HUMAN (1-374): 1.21e-78: 266: 14.00
+	Hs
		609219 FGFR3_HUMAN (20-260): 5.2e-21: 101: 9.09		KS6A3_HUMAN (1-353): 1.92e-78: 266: 13.83
+	Hs
		607975 FGFR4_HUMAN (47-355): 1.59e-17: 89.8: 11.67		KS6A1_HUMAN (1-359): 2.84e-81: 273: 14.32
+	Hs
		607926 FGFR4_HUMAN (47-355): 1.59e-17: 89.8: 11.67		KS6A3_HUMAN (1-353): 1.92e-78: 266: 13.83
+	Hs
		608180 FGFR4_HUMAN (47-355): 1.59e-17: 89.8: 11.67		KS6A6_HUMAN (1-349): 8.64e-77: 261: 15.01
+	Hs
		507863 FGFR1_HUMAN (6-360): 2.83e-24: 111: 10.90		CDK2_HUMAN (414-653): 1.01e-65: 219: 19.43
+	Hs
		609180 FGFR3_HUMAN (20-260): 5.2e-21: 101: 9.09		CDK2_HUMAN (414-653): 1.01e-65: 219: 19.43
+	Hs
		507867 FGFR1_HUMAN (6-360): 2.83e-24: 111: 10.90		MARK3_HUMAN (409-655): 3.06e-47: 179: 12.65