Interactor 1: BMR1A (P36894)
Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
Gene: BMPR1A

Interactor 2: TGFR2 (P37173)
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Gene: TGFBR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Activin_recp~ecTbetaR2, PK_Tyr_Ser-Thr~Pkinase, PK_Tyr_Ser-Thr~TGF_beta_GS
Common GO terms GO:0001701 - in utero embryonic development
GO:0002053 - positive regulation of mesenchymal cell proliferation
GO:0003148 - outflow tract septum morphogenesis
GO:0003151 - outflow tract morphogenesis
GO:0003186 - tricuspid valve morphogenesis
and 14 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 532
Hs

1 567
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Last updated: 15 Jul 2024