HitPredict

Interactor 1: ACV1B (P36896)
Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
Gene: ACVR1B

Interactor 2: FKB1A (P62942)
Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)
Gene: FKBP1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.805

Property	Details
Experiments	16720724, 15908921
Identification Methods	affinity chromatography technology, protein complementation assay, anti tag coimmunoprecipitation, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase, FKBP_C~TGF_beta_GS
Common GO terms	GO:0005829 - cytosol GO:0070411 - I-SMAD binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 505 Hs			1 108
+	Hs
		738325 BMR1A_HUMAN (19-505): 4.06e-145: 428: 49.29		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		738328 BMR1A_HUMAN (19-505): 4.06e-145: 428: 49.29		FKB1B_HUMAN (1-108): 2.61e-52: 161: 83.33
+	Hs
		738520 TGFR1_HUMAN (33-505): 3.15e-139: 412: 70.17		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		738525 TGFR1_HUMAN (33-505): 3.15e-139: 412: 70.17		FKB1B_HUMAN (1-108): 2.61e-52: 161: 83.33
+	Hs
		923822 ACVR1_HUMAN (12-502): 2.83e-137: 407: 48.20		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		739522 ACVL1_HUMAN (13-502): 5.72e-134: 398: 46.96		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		1034871 AMHR2_HUMAN (207-498): 6.66e-47: 173: 35.16		FKBP5_HUMAN (2-108): 3.73e-15: 71.3: 28.44