HitPredict

Interactor 1: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Interactor 2: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12429842
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001822 - kidney development GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 503 Hs			1 937
+	Mm
		1145507 TGFR1_MOUSE (26-503): 1.83e-145: 428: 97.30		AP2B1_MOUSE (1-937): 0: 926: 99.89
+	Hs
		738326 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Mm
		1143788 TGFR2_MOUSE (38-499): 3.76e-121: 368: 32.23		AP2B1_MOUSE (1-937): 0: 926: 99.89
+	Hs
		739946 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Dm
		52543 A1Z7L8_DROME (4-502): 7.07e-135: 405: 51.81		Q24253_DROME (1-937): 0: 804: 71.75
+	Dm
		1096901 Q7YU60_DROME (4-502): 2.59e-134: 403: 54.87		Q24253_DROME (1-937): 0: 804: 71.75
+	Hs
		321501 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		AP2A1_HUMAN (11-932): 0: 634: 16.97