Interactor 1: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Interactor 2: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 0.60 0.714

The method score is based on:

Property Details
Experiments 25872870, 35721120, 36889311, 12543979, 19758997
Identification Methods enzymatic study, affinity chromatography technology, pull down
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001701 - in utero embryonic development
GO:0005634 - nucleus
GO:0005886 - plasma membrane
GO:0006355 - regulation of DNA-templated transcription
GO:0007179 - transforming growth factor beta receptor signaling pathway
and 13 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 503
Hs

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Last updated: 15 Jul 2024