HitPredict

Interactor 1: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Interactor 2: ACVR1 (Q04771)
Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)
Gene: ACVR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.34 1.00 0.590

The method score is based on:

Property Details
Experiments 24658140
Identification Methods ubiquitin reconstruction
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Activin_recp~Activin_recp, PK_Tyr_Ser-Thr~Pkinase, Pkinase~TGF_beta_GS, PK_Tyr_Ser-Thr~TGF_beta_GS
Common GO terms GO:0001701 - in utero embryonic development
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004675 - transmembrane receptor protein serine/threonine kinase activity
GO:0005025 - transforming growth factor beta receptor activity, type I
and 18 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 503
Hs

1 509
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Last updated: 15 Jul 2024