HitPredict

Interactor 1: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Interactor 2: T22D1 (Q15714)
TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein)
Gene: TSC22D1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	21791611
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 503 Hs			1 1073
+	Hs
		981120 ACVR1_HUMAN (10-500): 8.17e-136: 403: 49.30		T22D1_HUMAN (1-1073): 7.61e-82: 291: 100.00
+	Hs
		122291 BMR1B_HUMAN (22-503): 1.21e-134: 400: 51.53		T22D1_HUMAN (1-1073): 7.61e-82: 291: 100.00
+	Hs
		738352 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		T22D1_HUMAN (1-1073): 7.61e-82: 291: 100.00
+	Hs
		738453 ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78		T22D1_HUMAN (1-1073): 7.61e-82: 291: 100.00
+	Hs
		739528 ACVL1_HUMAN (6-498): 2.71e-130: 389: 47.21		T22D1_HUMAN (1-1073): 7.61e-82: 291: 100.00
+	Hs
		739981 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		T22D1_HUMAN (1-1073): 7.61e-82: 291: 100.00