HitPredict

Interactor 1: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Interactor 2: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 503 Hs			1 258
+	Hs
		436183 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		738515 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		738527 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		738521 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		738517 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		436181 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		738516 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		436182 ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		738364 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		RHOU_HUMAN (1-258): 1.4e-83: 252: 100.00
+	Hs
		738320 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		738463 ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78		RHOU_HUMAN (1-258): 1.4e-83: 252: 100.00
+	Mm
		983316 ACVL1_MOUSE (7-497): 4.31e-133: 396: 46.11		RAC2_MOUSE (48-234): 5.46e-83: 248: 55.08
+	Hs
		564434 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		738577 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Hs
		738322 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		738321 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Mm
		983317 TGFR2_MOUSE (38-499): 3.76e-121: 368: 32.23		RAC2_MOUSE (48-234): 5.46e-83: 248: 55.08
+	Hs
		738409 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Hs
		738490 ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Mm
		1142495 ACVL1_MOUSE (7-497): 4.31e-133: 396: 46.11		RHOJ_MOUSE (40-220): 3.91e-63: 198: 53.59