HitPredict

Interactor 1: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Interactor 2: ACV1C (Q8NER5)
Activin receptor type-1C (EC 2.7.11.30) (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7)
Gene: ACVR1C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.47 1.00 0.691

The method score is based on:

Property Details
Experiments 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Activin_recp~Activin_recp, PK_Tyr_Ser-Thr~Pkinase, Pkinase~TGF_beta_GS, PK_Tyr_Ser-Thr~TGF_beta_GS
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0007399 - nervous system development
GO:0016361 - activin receptor activity, type I
and 4 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 503
Hs

1 493
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Last updated: 15 Jul 2024