HitPredict

Interactor 1: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Interactor 2: OTUB1 (Q96FW1)
Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)
Gene: OTUB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	25872870
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 503 Hs			1 271
+	Hs
		981132 ACVR1_HUMAN (10-500): 8.17e-136: 403: 49.30		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		122297 BMR1B_HUMAN (22-503): 1.21e-134: 400: 51.53		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		738396 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		738480 ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00