HitPredict

Interactor 1: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15350225
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0016020 - membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 503 Hs			1 903
+	Hs
		740040 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		125195 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125199 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		738403 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		738485 ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		738509 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		738312 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		738579 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		738578 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94
+	Mm
		56831 TGFR1_MOUSE (26-503): 1.83e-145: 428: 97.30		SMUF2_MOUSE (1-358): 2.99e-46: 179: 16.67
+	Hs
		981139 ACVR1_HUMAN (10-500): 8.17e-136: 403: 49.30		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		122298 BMR1B_HUMAN (22-503): 1.21e-134: 400: 51.53		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		738413 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		738495 ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		740065 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		740064 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94
+	Mm
		1143778 TGFR2_MOUSE (38-499): 3.76e-121: 368: 32.23		SMUF1_MOUSE (1-535): 3.62e-41: 164: 14.07
+	Dm
		1279501 Q95SI0_DROME (31-497): 6.57e-122: 368: 45.13		SMUF1_DROME (16-518): 1.15e-39: 161: 16.19
+	Hs
		1046388 BMPR2_HUMAN (48-495): 1.21e-92: 305: 29.21		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71