HitPredict

Interactor 1: TNR3 (P36941)
Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (Tumor necrosis factor C receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor receptor type III) (TNF-RIII) (TNFR-III)
Gene: LTBR

Interactor 2: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 0.60 0.755

The method score is based on:

Property Details
Experiments 10799510, 20348096, 26186194, 28514442, 33961781, 9162022, 14517219, 20732415, 15743811, 12571250
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0007165 - signal transduction
GO:0031625 - ubiquitin protein ligase binding
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:2001238 - positive regulation of extrinsic apoptotic signaling pathway
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 435
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024