HitPredict

Interactor 1: TNR3 (P36941)
Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (Tumor necrosis factor C receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor receptor type III) (TNF-RIII) (TNFR-III)
Gene: LTBR

Interactor 2: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	26186194, 28514442, 33961781, 9162022
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006915 - apoptotic process GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 416
+	Hs
		738659 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Mm
		761805 TNR3_MOUSE (1-419): 2.77e-106: 322: 68.17		TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77
+	Hs
		584392 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		639577 TNR5_HUMAN (15-287): 7.61e-52: 177: 26.01		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Mm
		626852 TNR1A_MOUSE (36-339): 2.63e-54: 188: 22.83		TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77
+	Mm
		192583 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77
+	Hs
		584390 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		639576 TNR5_HUMAN (15-287): 7.61e-52: 177: 26.01		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		584509 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98
+	Mm
		192585 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51
+	Hs
		129536 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF5_HUMAN (14-261): 1.36e-16: 83.8: 13.91
+	Hs
		738661 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Hs
		738694 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF4_HUMAN (27-136): 3.55e-09: 60.3: 17.86
+	Mm
		838552 TNR3_MOUSE (1-419): 2.77e-106: 322: 68.17		TRAF5_MOUSE (14-296): 7.86e-13: 71.9: 13.45
+	Mm
		838553 TNR3_MOUSE (1-419): 2.77e-106: 322: 68.17		TRAF3_MOUSE (1-262): 2.34e-12: 70.7: 16.37
+	Hs
		129532 TNR5_HUMAN (15-287): 7.61e-52: 177: 26.01		TRAF5_HUMAN (14-261): 1.36e-16: 83.8: 13.91
+	Mm
		192584 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF5_MOUSE (14-296): 7.86e-13: 71.9: 13.45
+	Hs
		584394 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Mm
		192587 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF3_MOUSE (1-262): 2.34e-12: 70.7: 16.37
+	Hs
		639578 TNR5_HUMAN (15-287): 7.61e-52: 177: 26.01		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77