HitPredict

Interactor 1: TNR3 (P36941)
Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (Tumor necrosis factor C receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor receptor type III) (TNF-RIII) (TNFR-III)
Gene: LTBR

Interactor 2: RNF31 (Q96EP0)
E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)
Gene: RNF31

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0031625 - ubiquitin protein ligase binding GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 435 Hs			1 1072
+	Hs
		584454 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		RNF31_HUMAN (1-1072): 0: 1111: 100.00
+	Hs
		639627 TNR5_HUMAN (15-287): 7.61e-52: 177: 26.01		RNF31_HUMAN (1-1072): 0: 1111: 100.00
+	Hs
		591388 TNR1B_HUMAN (9-231): 1.16e-44: 163: 30.84		RNF31_HUMAN (1-1072): 0: 1111: 100.00
+	Mm
		626875 TNR1A_MOUSE (36-339): 2.63e-54: 188: 22.83		RNF31_MOUSE (1-1072): 0: 1083: 85.54
+	Hs
		433200 LAMB1_HUMAN (33-191): 2.4e-10: 64.9: 15.98		ZRAN1_HUMAN (226-379): 5.88e-20: 97.7: 19.44
+	Hs
		502883 LAMC1_HUMAN (30-145): 6.4e-09: 60.3: 15.22		ZRAN1_HUMAN (226-379): 5.88e-20: 97.7: 19.44