HitPredict

Interactor 1: TNR3 (P36941)
Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (Tumor necrosis factor C receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor receptor type III) (TNF-RIII) (TNFR-III)
Gene: LTBR

Interactor 2: TRAF4 (Q9BUZ4)
TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83)
Gene: TRAF4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9626059
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0031625 - ubiquitin protein ligase binding GO:0046330 - positive regulation of JNK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 470
+	Hs
		738659 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Hs
		129536 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF5_HUMAN (2-465): 7.74e-104: 322: 24.95
+	Hs
		738661 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF3_HUMAN (3-465): 2.47e-92: 292: 22.99
+	Mm
		761805 TNR3_MOUSE (1-419): 2.77e-106: 322: 68.17		TRAF2_MOUSE (2-465): 1.21e-117: 355: 30.06
+	Mm
		838552 TNR3_MOUSE (1-419): 2.77e-106: 322: 68.17		TRAF5_MOUSE (2-465): 5.66e-113: 345: 26.95
+	Mm
		838553 TNR3_MOUSE (1-419): 2.77e-106: 322: 68.17		TRAF3_MOUSE (3-465): 4.11e-101: 315: 24.17
+	Hs
		738660 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF1_HUMAN (16-465): 6.07e-72: 235: 24.18
+	Hs
		301657 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRI37_HUMAN (5-465): 5.48e-55: 199: 13.81
+	Hs
		584390 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Mm
		626852 TNR1A_MOUSE (36-339): 2.63e-54: 188: 22.83		TRAF2_MOUSE (2-465): 1.21e-117: 355: 30.06
+	Mm
		192583 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF2_MOUSE (2-465): 1.21e-117: 355: 30.06
+	Hs
		639576 TNR5_HUMAN (15-287): 7.61e-52: 177: 26.01		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Mm
		192584 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF5_MOUSE (2-465): 5.66e-113: 345: 26.95
+	Hs
		129532 TNR5_HUMAN (15-287): 7.61e-52: 177: 26.01		TRAF5_HUMAN (2-465): 7.74e-104: 322: 24.95
+	Mm
		192587 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF3_MOUSE (3-465): 4.11e-101: 315: 24.17
+	Hs
		584394 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		TRAF3_HUMAN (3-465): 2.47e-92: 292: 22.99
+	Hs
		738686 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		RN166_HUMAN (9-146): 3.64e-16: 79.5: 25.90
+	Mm
		192585 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF6_MOUSE (3-464): 9.4e-87: 277: 25.00
+	Hs
		584509 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		TRAF6_HUMAN (3-464): 1.61e-84: 271: 24.79
+	Hs
		584392 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		TRAF1_HUMAN (16-465): 6.07e-72: 235: 24.18