HitPredict

Interactor 1: TNR3 (P36941)
Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (Tumor necrosis factor C receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor receptor type III) (TNF-RIII) (TNFR-III)
Gene: LTBR

Interactor 2: RN114 (Q9Y508)
E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)
Gene: RNF114

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 228
+	Hs
		738686 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		RN166_HUMAN (2-227): 1.03e-58: 187: 40.69
+	Hs
		129536 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF5_HUMAN (24-174): 2.07e-25: 105: 20.63
+	Hs
		738696 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRIM4_HUMAN (20-132): 1.34e-25: 105: 22.48
+	Hs
		738661 TNR3_HUMAN (1-435): 8.16e-134: 393: 100.00		TRAF3_HUMAN (24-163): 1.39e-21: 94.5: 19.10
+	Mm
		838552 TNR3_MOUSE (1-419): 2.77e-106: 322: 68.17		TRAF5_MOUSE (21-174): 5.9e-26: 106: 21.47
+	Mm
		838553 TNR3_MOUSE (1-419): 2.77e-106: 322: 68.17		TRAF3_MOUSE (24-163): 4.07e-23: 98.7: 19.66
+	Hs
		584437 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		RN138_HUMAN (17-225): 7.06e-49: 161: 31.09
+	Hs
		584509 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		TRAF6_HUMAN (19-179): 6.78e-26: 106: 20.48
+	Mm
		192585 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF6_MOUSE (19-179): 3.57e-27: 110: 19.76
+	Mm
		192584 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF5_MOUSE (21-174): 5.9e-26: 106: 21.47
+	Hs
		584394 TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43		TRAF3_HUMAN (24-163): 1.39e-21: 94.5: 19.10
+	Hs
		639668 TNR5_HUMAN (15-287): 7.61e-52: 177: 26.01		TRAF6_HUMAN (19-179): 6.78e-26: 106: 20.48
+	Hs
		129532 TNR5_HUMAN (15-287): 7.61e-52: 177: 26.01		TRAF5_HUMAN (24-174): 2.07e-25: 105: 20.63
+	Mm
		192587 TNR11_MOUSE (4-254): 6.04e-51: 183: 28.74		TRAF3_MOUSE (24-163): 4.07e-23: 98.7: 19.66
+	Mm
		648955 TNR5_MOUSE (13-286): 1.7e-49: 171: 22.99		TRAF6_MOUSE (19-179): 3.57e-27: 110: 19.76
+	Mm
		936208 TNR14_MOUSE (4-286): 1.42e-50: 173: 25.52		TRAF5_MOUSE (21-174): 5.9e-26: 106: 21.47
+	Mm
		936250 TNR27_MOUSE (44-367): 1.76e-48: 169: 15.50		TRAF6_MOUSE (19-179): 3.57e-27: 110: 19.76
+	Hs
		639578 TNR5_HUMAN (15-287): 7.61e-52: 177: 26.01		TRAF3_HUMAN (24-163): 1.39e-21: 94.5: 19.10
+	Mm
		648958 TNR5_MOUSE (13-286): 1.7e-49: 171: 22.99		TRAF3_MOUSE (24-163): 4.07e-23: 98.7: 19.66
+	Hs
		1024763 TNR27_HUMAN (44-367): 8.89e-48: 167: 18.71		TRAF3_HUMAN (24-163): 1.39e-21: 94.5: 19.10