HitPredict

Interactor 1: SRBP1 (P36956)
Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)]
Gene: SREBF1

Interactor 2: RNF4 (P78317)
E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF)
Gene: RNF4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29180619
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1147 Hs			1 190
+	Mm
		1125394 SRBP1_MOUSE (1-1147): 0: 881: 78.31		BRE1A_MOUSE (23-190): 8.95e-24: 99.7: 19.89
+	Hs
		584889 SRBP1_HUMAN (1-1147): 0: 910: 100.00		RO52_HUMAN (120-187): 1.12e-11: 64.3: 34.78
+	Hs
		940809 IF4G1_HUMAN (5-519): 4.17e-10: 66.5: 9.86		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		941143 KMT2E_HUMAN (1-372): 3.95e-09: 63.4: 9.25		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00