HitPredict

Interactor 1: ACVL1 (P37023)
Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)
Gene: ACVRL1

Interactor 2: FKB1A (P62942)
Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)
Gene: FKBP1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.555

Property	Details
Experiments	19592636
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	FKBP_C~PK_Tyr_Ser-Thr, FKBP_C~TGF_beta_GS
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 503 Hs			1 108
+	Hs
		738325 BMR1A_HUMAN (30-497): 4.2e-134: 400: 45.91		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		738328 BMR1A_HUMAN (30-497): 4.2e-134: 400: 45.91		FKB1B_HUMAN (1-108): 2.61e-52: 161: 83.33
+	Hs
		738520 TGFR1_HUMAN (33-495): 3.97e-131: 391: 48.63		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		923822 ACVR1_HUMAN (10-501): 2.48e-130: 390: 59.00		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		738525 TGFR1_HUMAN (33-495): 3.97e-131: 391: 48.63		FKB1B_HUMAN (1-108): 2.61e-52: 161: 83.33
+	Hs
		738439 ACV1B_HUMAN (14-493): 1.88e-123: 371: 47.86		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		1034871 AMHR2_HUMAN (188-497): 1.03e-32: 133: 31.16		FKBP5_HUMAN (2-108): 3.73e-15: 71.3: 28.44