HitPredict

Interactor 1: ACVL1 (P37023)
Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)
Gene: ACVRL1

Interactor 2: GDF2 (Q9UK05)
Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9)
Gene: GDF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 0.60 0.655

The method score is based on:

Property Details
Experiments 25237187, 17311849, 28564608
Identification Methods pull down
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001525 - angiogenesis
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0010596 - negative regulation of endothelial cell migration
GO:0030308 - negative regulation of cell growth
and 12 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 503
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024