Interactor 1: SCNNA (P37088)
Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (ENaCA) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
Gene: SCNN1A

Interactor 2: SCNNB (P51168)
Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (ENaCB) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
Gene: SCNN1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.854

The method score is based on:

Property Details
Experiments 22526458, 27903760, 21775436
Identification Methods protein complementation assay, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains ASC~ASC
Common GO terms GO:0005886 - plasma membrane
GO:0006883 - intracellular sodium ion homeostasis
GO:0008217 - regulation of blood pressure
GO:0009897 - external side of plasma membrane
GO:0015280 - ligand-gated sodium channel activity
and 13 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 669
Hs

1 640
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Gg
+ Mm
+ Hs

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Last updated: 15 Jul 2024