HitPredict

Interactor 1: SCNNA (P37088)
Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (ENaCA) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
Gene: SCNN1A

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28137758
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 669 Hs			1 4374
+	Hs
		739603 SCNNA_HUMAN (1-669): 0: 729: 100.00		ITCH_HUMAN (3507-4372): 0: 672: 23.10
+	Hs
		125197 SCNNA_HUMAN (1-669): 0: 729: 100.00		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		739604 SCNNA_HUMAN (1-669): 0: 729: 100.00		NED4L_HUMAN (3542-4372): 0: 618: 27.53
+	Hs
		739608 SCNNA_HUMAN (1-669): 0: 729: 100.00		WWP1_HUMAN (3507-4372): 0: 613: 22.55
+	Hs
		739582 SCNNA_HUMAN (1-669): 0: 729: 100.00		NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46
+	Rn
		739625 SCNNA_RAT (1-668): 0: 680: 82.74		NEDD4_RAT (3603-4372): 0: 630: 26.96
+	Mm
		808356 SCNNA_MOUSE (1-665): 0: 661: 82.66		NEDD4_MOUSE (3603-4372): 0: 639: 27.33
+	Mm
		93272 SCNNA_MOUSE (1-665): 0: 661: 82.66		E9PXB7_MOUSE (3641-4372): 0: 620: 29.18
+	Hs
		739596 SCNNA_HUMAN (1-669): 0: 729: 100.00		HECW1_HUMAN (3082-4373): 1.49e-161: 549: 18.31
+	Mm
		808383 SCNNG_MOUSE (36-650): 0: 576: 33.12		NEDD4_MOUSE (3603-4372): 0: 639: 27.33
+	Rn
		739631 SCNNG_RAT (36-650): 0: 568: 32.75		NEDD4_RAT (3603-4372): 0: 630: 26.96
+	Rn
		739628 SCNNB_RAT (54-666): 0: 566: 31.22		NEDD4_RAT (3603-4372): 0: 630: 26.96
+	Mm
		93286 SCNNG_MOUSE (36-650): 0: 576: 33.12		E9PXB7_MOUSE (3641-4372): 0: 620: 29.18
+	Hs
		125257 SCNNG_HUMAN (36-650): 0: 568: 33.44		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		125256 SCNNB_HUMAN (54-666): 0: 564: 30.54		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		845991 SCNNG_HUMAN (36-650): 0: 568: 33.44		NED4L_HUMAN (3542-4372): 0: 618: 27.53
+	Rn
		739630 SCNNG_RAT (36-650): 0: 568: 32.75		Q4V8H7_RAT (3507-4372): 0: 616: 22.54
+	Hs
		808050 SCNNG_HUMAN (36-650): 0: 568: 33.44		NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46
+	Hs
		808049 SCNNB_HUMAN (54-666): 0: 564: 30.54		NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46
+	Hs
		845975 SCNNB_HUMAN (54-666): 0: 564: 30.54		HECW1_HUMAN (3082-4373): 1.49e-161: 549: 18.31