HitPredict

Interactor 1: SCNNA (P37088)
Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (ENaCA) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
Gene: SCNN1A

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11244092
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 669 Hs			1 903
+	Hs
		739608 SCNNA_HUMAN (1-669): 0: 729: 100.00		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		125197 SCNNA_HUMAN (1-669): 0: 729: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		739604 SCNNA_HUMAN (1-669): 0: 729: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Rn
		739630 SCNNG_RAT (36-650): 0: 568: 32.75		Q4V8H7_RAT (1-903): 0: 837: 57.04
+	Hs
		739582 SCNNA_HUMAN (1-669): 0: 729: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		125257 SCNNG_HUMAN (36-650): 0: 568: 33.44		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125256 SCNNB_HUMAN (54-666): 0: 564: 30.54		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		845991 SCNNG_HUMAN (36-650): 0: 568: 33.44		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Mm
		93272 SCNNA_MOUSE (1-665): 0: 661: 82.66		E9PXB7_MOUSE (86-900): 0: 654: 34.22
+	Hs
		739597 SCNNA_HUMAN (1-669): 0: 729: 100.00		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		808050 SCNNG_HUMAN (36-650): 0: 568: 33.44		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		808049 SCNNB_HUMAN (54-666): 0: 564: 30.54		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Mm
		93286 SCNNG_MOUSE (36-650): 0: 576: 33.12		E9PXB7_MOUSE (86-900): 0: 654: 34.22
+	Rn
		739625 SCNNA_RAT (1-668): 0: 680: 82.74		NEDD4_RAT (7-426): 3.03e-54: 205: 18.07
+	Mm
		808356 SCNNA_MOUSE (1-665): 0: 661: 82.66		NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38
+	Hs
		739596 SCNNA_HUMAN (1-669): 0: 729: 100.00		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76
+	Mm
		808383 SCNNG_MOUSE (36-650): 0: 576: 33.12		NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38
+	Rn
		739631 SCNNG_RAT (36-650): 0: 568: 32.75		NEDD4_RAT (7-426): 3.03e-54: 205: 18.07
+	Rn
		739628 SCNNB_RAT (54-666): 0: 566: 31.22		NEDD4_RAT (7-426): 3.03e-54: 205: 18.07
+	Hs
		845975 SCNNB_HUMAN (54-666): 0: 564: 30.54		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76