HitPredict

Interactor 1: SCNNA (P37088)
Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (ENaCA) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
Gene: SCNN1A

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.747

Property	Details
Experiments	12876068, 15328345, 16844684, 11802777, 26651153, 11244092, 14556380, 17502380, 16416336, 18701608
Identification Methods	unspecified method, affinity chromatography technology, far western blotting, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 669 Hs			1 975
+	Hs
		845991 SCNNG_HUMAN (36-650): 0: 568: 33.44		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Mm
		93272 SCNNA_MOUSE (1-665): 0: 661: 82.66		E9PXB7_MOUSE (122-975): 0: 863: 95.79
+	Hs
		739608 SCNNA_HUMAN (1-669): 0: 729: 100.00		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		739603 SCNNA_HUMAN (1-669): 0: 729: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Mm
		808356 SCNNA_MOUSE (1-665): 0: 661: 82.66		NEDD4_MOUSE (12-975): 0: 794: 55.19
+	Hs
		739582 SCNNA_HUMAN (1-669): 0: 729: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125197 SCNNA_HUMAN (1-669): 0: 729: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Mm
		93286 SCNNG_MOUSE (36-650): 0: 576: 33.12		E9PXB7_MOUSE (122-975): 0: 863: 95.79
+	Mm
		808383 SCNNG_MOUSE (36-650): 0: 576: 33.12		NEDD4_MOUSE (12-975): 0: 794: 55.19
+	Rn
		739630 SCNNG_RAT (36-650): 0: 568: 32.75		Q4V8H7_RAT (1-972): 0: 785: 33.71
+	Hs
		808050 SCNNG_HUMAN (36-650): 0: 568: 33.44		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808049 SCNNB_HUMAN (54-666): 0: 564: 30.54		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125257 SCNNG_HUMAN (36-650): 0: 568: 33.44		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125256 SCNNB_HUMAN (54-666): 0: 564: 30.54		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		739597 SCNNA_HUMAN (1-669): 0: 729: 100.00		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Rn
		739625 SCNNA_RAT (1-668): 0: 680: 82.74		NEDD4_RAT (13-452): 2.05e-63: 233: 46.82
+	Rn
		739631 SCNNG_RAT (36-650): 0: 568: 32.75		NEDD4_RAT (13-452): 2.05e-63: 233: 46.82
+	Rn
		739628 SCNNB_RAT (54-666): 0: 566: 31.22		NEDD4_RAT (13-452): 2.05e-63: 233: 46.82
+	Hs
		739596 SCNNA_HUMAN (1-669): 0: 729: 100.00		HECW1_HUMAN (144-528): 1.92e-09: 64.2: 13.73
+	Hs
		845975 SCNNB_HUMAN (54-666): 0: 564: 30.54		HECW1_HUMAN (144-528): 1.92e-09: 64.2: 13.73