HitPredict

Interactor 1: SCNNG (P37091)
Amiloride-sensitive sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (Gamma-ENaC) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG)
Gene: Scnn1g

Interactor 2: NEDD4 (Q62940)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4)
Gene: NEDD4

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	11805112, 8665844
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006814 - sodium ion transport GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 650 Rn			1 887
+	Mm
		808383 SCNNG_MOUSE (1-650): 0: 784: 96.49		NEDD4_MOUSE (1-887): 0: 910: 94.59
+	Hs
		845991 SCNNG_HUMAN (1-650): 0: 768: 86.62		NED4L_HUMAN (58-887): 0: 770: 56.21
+	Rn
		739628 SCNNB_RAT (17-634): 0: 592: 36.15		NEDD4_RAT (1-887): 0: 927: 100.00
+	Hs
		808050 SCNNG_HUMAN (1-650): 0: 768: 86.62		NEDD4_HUMAN (154-887): 0: 724: 78.86
+	Rn
		739630 SCNNG_RAT (1-650): 0: 791: 100.00		Q4V8H7_RAT (67-884): 0: 670: 32.03
+	Hs
		125257 SCNNG_HUMAN (1-650): 0: 768: 86.62		WWP2_HUMAN (72-884): 0: 677: 33.30
+	Mm
		93286 SCNNG_MOUSE (1-650): 0: 784: 96.49		E9PXB7_MOUSE (169-887): 0: 651: 57.16
+	Hs
		845978 SCNNB_HUMAN (7-634): 0: 599: 35.89		NED4L_HUMAN (58-887): 0: 770: 56.21
+	Hs
		739604 SCNNA_HUMAN (24-631): 0: 583: 33.33		NED4L_HUMAN (58-887): 0: 770: 56.21
+	Hs
		808049 SCNNB_HUMAN (7-634): 0: 599: 35.89		NEDD4_HUMAN (154-887): 0: 724: 78.86
+	Hs
		739582 SCNNA_HUMAN (24-631): 0: 583: 33.33		NEDD4_HUMAN (154-887): 0: 724: 78.86
+	Hs
		845977 SCNNB_HUMAN (7-634): 0: 599: 35.89		ITCH_HUMAN (62-884): 0: 686: 31.69
+	Hs
		125256 SCNNB_HUMAN (7-634): 0: 599: 35.89		WWP2_HUMAN (72-884): 0: 677: 33.30
+	Hs
		739603 SCNNA_HUMAN (24-631): 0: 583: 33.33		ITCH_HUMAN (62-884): 0: 686: 31.69
+	Hs
		125197 SCNNA_HUMAN (24-631): 0: 583: 33.33		WWP2_HUMAN (72-884): 0: 677: 33.30
+	Mm
		93285 SCNNB_MOUSE (17-634): 0: 579: 35.99		E9PXB7_MOUSE (169-887): 0: 651: 57.16
+	Hs
		739608 SCNNA_HUMAN (24-631): 0: 583: 33.33		WWP1_HUMAN (76-884): 0: 642: 31.52
+	Hs
		739597 SCNNA_HUMAN (24-631): 0: 583: 33.33		HUWE1_HUMAN (158-885): 2.08e-167: 542: 27.96
+	Hs
		845975 SCNNB_HUMAN (7-634): 0: 599: 35.89		HECW1_HUMAN (22-500): 2.12e-18: 93: 13.24
+	Hs
		739596 SCNNA_HUMAN (24-631): 0: 583: 33.33		HECW1_HUMAN (22-500): 2.12e-18: 93: 13.24