HitPredict

Interactor 1: TGFR2 (P37173)
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Gene: TGFBR2

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	26807171, 18922473
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001701 - in utero embryonic development GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0032147 - activation of protein kinase activity GO:0043011 - myeloid dendritic cell differentiation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 567 Hs			1 522
+	Hs
		646084 AVR2A_HUMAN (37-549): 8.74e-128: 385: 32.83		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		738597 TGFR1_HUMAN (48-548): 3.13e-117: 358: 29.62		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		122301 BMR1B_HUMAN (55-548): 1.98e-114: 351: 27.82		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		740054 TGFR2_HUMAN (1-567): 1.25e-149: 443: 100.00		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		738575 TGFR1_HUMAN (48-548): 3.13e-117: 358: 29.62		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		740012 TGFR2_HUMAN (1-567): 1.25e-149: 443: 100.00		LNX2_HUMAN (58-183): 1.56e-11: 69.1: 21.88