HitPredict

Interactor 1: PPARG (P37231)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
Gene: PPARG

Interactor 2: MK09 (P45984)
Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
Gene: MAPK9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression GO:0042752 - regulation of circadian rhythm and 1 others more... GO:0048511 - rhythmic process
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 505 Hs			1 424
+	Hs
		377173 GCR_HUMAN (18-503): 1.99e-98: 315: 17.85		MK08_HUMAN (1-424): 1.17e-153: 443: 80.80
+	Hs
		611396 NR4A1_HUMAN (4-503): 3.33e-99: 312: 20.83		MK08_HUMAN (1-424): 1.17e-153: 443: 80.80
+	Hs
		782498 HNF4A_HUMAN (114-501): 4.62e-100: 311: 21.34		MK08_HUMAN (1-424): 1.17e-153: 443: 80.80
+	Hs
		960086 PPARA_HUMAN (31-505): 4.22e-120: 362: 54.18		CDK3_HUMAN (23-322): 4.06e-132: 383: 33.01
+	Hs
		369006 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		CDK2_HUMAN (23-330): 2.27e-136: 394: 32.48
+	Hs
		658821 PPARG_HUMAN (1-505): 2.47e-165: 479: 100.00		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50
+	Hs
		265865 NR1I2_HUMAN (139-501): 1.19e-104: 321: 26.26		MK07_HUMAN (16-385): 3.24e-132: 401: 37.53
+	Hs
		611449 NR4A1_HUMAN (4-503): 3.33e-99: 312: 20.83		MK14_HUMAN (4-375): 9.3e-130: 379: 48.00
+	Mm
		521436 NR4A1_MOUSE (8-503): 1.14e-96: 306: 20.60		MK14_MOUSE (4-375): 3.76e-130: 381: 48.00
+	Hs
		587121 RXRA_HUMAN (21-502): 4.79e-118: 356: 23.22		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50
+	Hs
		369038 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50
+	Hs
		509908 VDR_HUMAN (139-503): 4.55e-108: 330: 26.68		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50
+	Hs
		487905 RARA_HUMAN (45-503): 3.89e-102: 316: 25.22		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50
+	Hs
		658827 HNF4A_HUMAN (114-501): 4.62e-100: 311: 21.34		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50
+	Hs
		659019 ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50