HitPredict

Interactor 1: PPARG (P37231)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
Gene: PPARG

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	22584573, 23178929, 31319193, 22078880
Identification Methods	enzymatic study, pull down, affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription GO:0048511 - rhythmic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 505 Hs			1 292
+	Hs
		960086 PPARA_HUMAN (31-505): 4.22e-120: 362: 54.18		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		369006 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		414730 RXRA_HUMAN (21-502): 4.79e-118: 356: 23.22		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		368820 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		369206 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24
+	Dm
		709143 ECR_DROME (108-501): 2.18e-101: 325: 25.82		CDK5_DROME (1-288): 1.68e-132: 378: 79.17
+	Mm
		509486 ERR2_MOUSE (25-502): 1.44e-103: 318: 19.75		CDK1_MOUSE (1-289): 2.16e-133: 381: 56.70
+	Mm
		1142712 ERR2_MOUSE (25-502): 1.44e-103: 318: 19.75		Q99JW7_MOUSE (3-289): 1.44e-131: 376: 56.40
+	Dm
		618428 ECR_DROME (108-501): 2.18e-101: 325: 25.82		CDK2_DROME (1-289): 8.92e-127: 365: 49.48