HitPredict

Interactor 1: PPARG (P37231)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
Gene: PPARG

Interactor 2: NCOA1 (Q15788)
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Gene: NCOA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 17449869, 9744270, 20717101, 17312272, 30813326, 30595551, 17468099, 10731636, 11877444, 17011503, 17704298, 15888456, 17513608, 19596656, 10339548, 22070604, 23178929, 16373399, 11500849, 11027271 and 4 others

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Identification Methods pull down, x-ray crystallography, unspecified method, affinity chromatography technology, two hybrid, fluorescent resonance energy transfer
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Hormone_recep~SRC-1
Common GO terms GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
and 8 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024