HitPredict

Interactor 1: PPARG (P37231)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
Gene: PPARG

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	11877444, 15888456, 19596656, 23178929, 35140242, 11500849, 11027271, 15604093
Identification Methods	unspecified method, pull down, proximity labelling technology, fluorescent resonance energy transfer, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Hs			1 1424
+	Hs
		992458 PPARA_HUMAN (31-505): 4.22e-120: 362: 54.18		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		587212 RXRA_HUMAN (21-502): 4.79e-118: 356: 23.22		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		975487 PPARD_HUMAN (99-505): 1.47e-115: 349: 60.29		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		740529 PPARG_HUMAN (1-505): 2.47e-165: 479: 100.00		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Mm
		740717 PPARG_MOUSE (1-505): 1.57e-164: 477: 96.04		NCOA2_MOUSE (1-1422): 1.73e-98: 349: 38.93
+	Hs
		740535 PPARG_HUMAN (1-505): 2.47e-165: 479: 100.00		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		587195 RXRA_HUMAN (21-502): 4.79e-118: 356: 23.22		NPAS2_HUMAN (19-807): 7.51e-111: 372: 16.20
+	Hs
		992420 PPARA_HUMAN (31-505): 4.22e-120: 362: 54.18		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		587173 RXRA_HUMAN (21-502): 4.79e-118: 356: 23.22		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		126103 RXRA_HUMAN (21-502): 4.79e-118: 356: 23.22		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Hs
		975430 PPARD_HUMAN (99-505): 1.47e-115: 349: 60.29		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		369673 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		992422 PPARA_HUMAN (31-505): 4.22e-120: 362: 54.18		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		181498 RXRA_HUMAN (21-502): 4.79e-118: 356: 23.22		CLOCK_HUMAN (1-791): 2.47e-78: 279: 13.73
+	Hs
		587177 RXRA_HUMAN (21-502): 4.79e-118: 356: 23.22		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		975432 PPARD_HUMAN (99-505): 1.47e-115: 349: 60.29		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		369684 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		369025 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		ARNT_HUMAN (6-642): 2.95e-76: 272: 16.01
+	Hs
		369099 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		AHR_HUMAN (12-793): 4.1e-70: 255: 12.66
+	Hs
		740556 PPARG_HUMAN (1-505): 2.47e-165: 479: 100.00		KMT2C_HUMAN (471-1383): 2.87e-11: 70.9: 12.87