HitPredict

Interactor 1: VRP1 (P37370)
Verprolin
Gene: VRP1

Interactor 2: ARPC1 (P38328)
Actin-related protein 2/3 complex subunit 1 (Arp2/3 complex 41 kDa subunit) (p41-ARC)
Gene: ARC40

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	18467557, 37968396
Identification Methods	protein complementation assay, affinity chromatography technology, dihydrofolate reductase reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030479 - actin cortical patch GO:2000601 - positive regulation of Arp2/3 complex-mediated actin nucleation
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 817 Sc			1 384
+	Hs
		1281391 PRR36_HUMAN (1-781): 2.97e-22: 105: 12.68		FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89
+	Hs
		152678 KMT2D_HUMAN (4-757): 1.05e-10: 68.2: 10.40		FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89
+	Hs
		878234 CIC_HUMAN (10-707): 1.45e-10: 67.4: 13.59		SEC13_HUMAN (31-313): 1.31e-64: 210: 20.89
+	Hs
		929460 MDC1_HUMAN (23-817): 1.05e-25: 116: 10.81		RACK1_HUMAN (1-141): 2.31e-20: 92.5: 12.93
+	Mm
		903669 KMT2C_MOUSE (1-571): 4.17e-11: 69.2: 14.19		WDR5_MOUSE (182-383): 7.51e-36: 135: 12.75
+	Hs
		152622 KMT2D_HUMAN (4-757): 1.05e-10: 68.2: 10.40		WDR5_HUMAN (182-383): 7.51e-36: 135: 12.75
+	Hs
		903450 CIC_HUMAN (10-707): 1.45e-10: 67.4: 13.59		WDR5_HUMAN (182-383): 7.51e-36: 135: 12.75
+	Hs
		903374 KMT2C_HUMAN (24-667): 1.95e-10: 66.9: 12.98		WDR5_HUMAN (182-383): 7.51e-36: 135: 12.75
+	Sp
		142026 SEC31_SCHPO (142-480): 4.82e-13: 75.4: 20.47		SEC13_SCHPO (31-294): 1.28e-31: 123: 13.90
+	Hs
		152663 KMT2D_HUMAN (4-757): 1.05e-10: 68.2: 10.40		WDR5B_HUMAN (181-383): 4.15e-33: 127: 12.68
+	Hs
		1074805 CIC_HUMAN (10-707): 1.45e-10: 67.4: 13.59		TAF5_HUMAN (144-384): 4.99e-31: 126: 12.94
+	Dm
		1370295 Q9VLS7_DROME (18-794): 4.08e-15: 82.4: 11.71		POC1_DROME (1-92): 5.55e-17: 83.6: 19.36
+	Hs
		929620 CIC_HUMAN (10-707): 1.45e-10: 67.4: 13.59		RACK1_HUMAN (1-141): 2.31e-20: 92.5: 12.93
+	Sc
		758551 SEC31_YEAST (309-712): 1.57e-10: 67.3: 20.90		SEC13_YEAST (19-190): 1.7e-09: 60.3: 13.33